Interleukin-11 (IL-11) in aseptic loosening of total hip replacement (THR)

Scand J Rheumatol. 1998;27(5):363-7. doi: 10.1080/03009749850154393.


The chronic inflammatory response to abrasion particles from total hip replacement (THR) is believed to cause osteolysis and to contribute to prosthetic loosening. The expression of interleukin-11(IL-11) and its major cellular sources in the interface and pseudocapsular tissues obtained from total hip revisions performed for aseptic loosening were investigated. The avidin-biotin-peroxidase complex (ABC) and alkaline phosphatase-anti-alkaline phosphatase (APAAP) methods were used for staining and VIDAS image analysis for quantification. IL-11 was found in the interface and pseudocapsular tissues in the aseptic loosening of THR. IL-11 containing cells were more numerous in the interface (760 +/- 171 cells) and pseudocapsular tissues (684 +/- 171 cells) than in the control synovial tissue (235 +/- 68 cells). Because IL-11 is an important component of cytokine network mediating osteoblast-osteoclast communication in normal and pathological bone remodeling, the current findings suggest that IL-11 may contribute to periprosthetic osteolysis and to the loosening of THR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Arthroplasty, Replacement, Hip*
  • Asepsis
  • Female
  • Hip Prosthesis*
  • Humans
  • Image Processing, Computer-Assisted
  • Immunoenzyme Techniques
  • Interleukin-11 / adverse effects
  • Interleukin-11 / metabolism*
  • Joint Capsule / metabolism*
  • Joint Capsule / pathology
  • Male
  • Middle Aged
  • Osteolysis / etiology
  • Osteolysis / metabolism
  • Osteolysis / pathology
  • Prosthesis Failure*
  • Synovial Membrane / metabolism*
  • Synovial Membrane / pathology


  • Interleukin-11