Alveolar rhabdomyosarcoma in a 68-year-old patient identified by cytogenetic analysis of bone marrow

Cancer Genet Cytogenet. 1998 Nov;107(1):43-7. doi: 10.1016/s0165-4608(98)00061-2.

Abstract

Pancytopenia and fulminant disseminated intravascular coagulation in a 68-year-old woman suggested an acute hematologic malignancy. However, cytogenetic analysis on a bone marrow sample revealed a near-tetraploid karyotype with an isochromosome 1q and a translocation (2;13) (q35;q14), which was suggestive of an alveolar rhabdomyosarcoma (ARMS). This diagnosis was subsequently confirmed by indirect immunohistochemistry. ARMS has not yet been observed in a patient of this age. Thus, our case underlines the importance of cytogenetics, to establish an a priori unexpected tumor diagnosis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Bone Marrow Examination
  • Cervical Vertebrae*
  • Chromosomes, Human, Pair 1 / genetics
  • Chromosomes, Human, Pair 13 / genetics*
  • Chromosomes, Human, Pair 2 / genetics*
  • Fatal Outcome
  • Female
  • Fluorescent Antibody Technique, Indirect
  • Genetic Markers
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Rhabdomyosarcoma, Alveolar / genetics*
  • Rhabdomyosarcoma, Alveolar / pathology
  • Spinal Neoplasms / genetics*
  • Spinal Neoplasms / pathology
  • Translocation, Genetic*

Substances

  • Genetic Markers