Did the four human cancer cell lines DLD-1, HCT-15, HCT-8, and HRT-18 originate from one and the same patient?

Cancer Genet Cytogenet. 1998 Nov;107(1):76-9. doi: 10.1016/s0165-4608(98)00081-8.


Four human colon cancer cell lines, HCT-8, HRT-18, DLD-1, and HCT-15, with an epithelioid morphotype reproducibly formed alpha-catenin-deficient round cells. Using DNA fingerprinting, we found that these four cell lines have an identical genetic background. Our finding strongly suggests a genetic background for the reproducible loss of alpha-catenin and the ensuing acquisition of invasiveness in all four cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colonic Neoplasms / genetics*
  • Colonic Neoplasms / pathology
  • Cytoskeletal Proteins / analysis
  • Cytoskeletal Proteins / genetics*
  • DNA Fingerprinting*
  • DNA, Neoplasm / genetics*
  • Genetic Markers
  • Humans
  • Karyotyping
  • Neoplasm Proteins / analysis
  • Neoplasm Proteins / genetics*
  • Trans-Activators*
  • Tumor Cells, Cultured* / pathology
  • beta Catenin


  • CTNNB1 protein, human
  • Cytoskeletal Proteins
  • DNA, Neoplasm
  • Genetic Markers
  • Neoplasm Proteins
  • Trans-Activators
  • beta Catenin