The Drosophila protein Dof is specifically required for FGF signaling

Mol Cell. 1998 Oct;2(4):515-25. doi: 10.1016/s1097-2765(00)80151-3.


Receptor tyrosine kinases (RTKs) transmit signals to the cell nucleus via the MAP kinase (MAPK) cascade, using specific molecules to link the activated receptors to the MAPK cascade activator, Ras. We have identified a component of the FGF receptor (FGFR) signal transduction pathway, Downstream of FGFR (Dof). Dof is an intracellular protein that is essential for signal transmission by the FGFR and acts downstream of the receptor and upstream of Ras. Unlike other signaling molecules that act downstream of RTKs, Dof is not expressed ubiquitously but is present exclusively in cells that express FGFRs. Dof is needed in these cells for activation of the MAPK cascade via FGF signaling, but not for activation via other RTK ligands. Dof therefore appears to be committed exclusively to FGFR-mediated signal transduction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism
  • Cell Movement / physiology
  • Cytoplasm / chemistry
  • DNA, Complementary
  • Drosophila / chemistry
  • Drosophila / enzymology
  • Drosophila / growth & development*
  • Drosophila Proteins*
  • Epistasis, Genetic
  • Gene Expression Regulation, Developmental
  • Insect Proteins / genetics*
  • Insect Proteins / metabolism*
  • Insect Proteins / physiology
  • Mesoderm / chemistry
  • Mesoderm / cytology
  • Molecular Sequence Data
  • Morphogenesis / physiology
  • Mutation / physiology
  • Receptors, Fibroblast Growth Factor / physiology*
  • Signal Transduction / physiology*
  • Trachea / growth & development


  • DNA, Complementary
  • Drosophila Proteins
  • Insect Proteins
  • Receptors, Fibroblast Growth Factor
  • stumps protein, Drosophila
  • Calcium-Calmodulin-Dependent Protein Kinases

Associated data

  • GENBANK/AJ010641
  • GENBANK/AJ010642