Effect of LAAM dose on opiate use in opioid-dependent patients. A pilot study

Am J Addict. Fall 1998;7(4):272-82.

Abstract

The authors conducted a 16-week study with nine opioid-dependent individuals (six male; four white/two African American/three Hispanic; age 36.8 +/- 2.2 years). Participants were assigned to either a low-dose (165 mg/week; n = 5) or high-dose (330 mg/week; n = 4) Levo-alpha-acetylmethadol (LAAM) condition according to a randomized, double-blind, within-subjects crossover design, such that they were inducted onto one maintenance dose for 4 weeks and then were crossed over to receive the converse for 4 weeks. Subsequently, individuals underwent detoxification from LAAM. Eight of nine participants completed the study protocol. The proportion of urine samples positive for opiates was 0.22 +/- 0.08 and 0.53 +/- 0.12, under the high- and low-dose conditions, respectively (F = 11.8; P = 0.01). These results show that LAAM dose regimen affects the degree of abstinence from opioids.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Male
  • Methadyl Acetate / administration & dosage
  • Methadyl Acetate / therapeutic use*
  • Narcotics / administration & dosage
  • Narcotics / therapeutic use*
  • Narcotics / urine
  • Opioid-Related Disorders / drug therapy*
  • Pilot Projects
  • Substance Withdrawal Syndrome

Substances

  • Narcotics
  • Methadyl Acetate