Circadian rhythm of pain in male mice

Gen Pharmacol. 1998 Nov;31(5):809-10. doi: 10.1016/s0306-3623(98)00076-7.


1. Circadian rhythm of pain in response to the thermal stimuli was assessed in male mice. 2. The hot-plate method was used. Response latencies were measured every 2 hours and showed a sinusoidal rhythm. 3. Minimal latencies were observed at 10 and 20 h, the highest were obtained at 12 and 4 hours. 4. The circadian changes in pain sensitivity may play an important role in many experiments on stress and post-stress analgesia as well as on susceptibility to pharmacological agents.

MeSH terms

  • Animals
  • Circadian Rhythm*
  • Male
  • Mice
  • Pain / physiopathology*
  • Pain Measurement
  • Reaction Time