Graves' disease presenting as localized myxedema in a thigh donor graft site

J Am Acad Dermatol. 1998 Nov;39(5 Pt 2):846-9. doi: 10.1016/s0190-9622(98)70363-9.


Pretibial myxedema, exophthalmus, and thyroid acropachy are the classic manifestations of Graves' Disease. However, myxedema in Graves' Disease can occur in locations other than the pretibial surfaces. Furthermore, with systemic symptoms, localized myxedema may occur at sites of trauma or scarring. We describe a patient with localized myxedema on the thigh at the site of a donor skin graft as the initial presentation of Graves' Disease.

Publication types

  • Case Reports

MeSH terms

  • Amputation
  • Follow-Up Studies
  • Graves Disease / complications*
  • Humans
  • Leg Dermatoses / etiology*
  • Leg Ulcer / etiology
  • Leg Ulcer / surgery
  • Male
  • Middle Aged
  • Myxedema / etiology*
  • Skin Transplantation / methods
  • Thigh / pathology*
  • Venous Insufficiency / complications