BEHAB/brevican: a brain-specific lectican implicated in gliomas and glial cell motility

Curr Opin Neurobiol. 1998 Oct;8(5):576-81. doi: 10.1016/s0959-4388(98)80083-4.


Several recent findings have advanced our understanding of the composition and function of the brain extracellular matrix (ECM). BEHAB/brevican, a recently identified CNS-specific proteoglycan, is a component of the brain ECM and is upregulated during glial cell motility. It is expressed at high levels during development, in response to injury, and in primary brain tumors. Cleavage of the BEHAB/brevican protein may increase invasion of tumor cells.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Brain Chemistry / physiology
  • Brain Neoplasms / metabolism*
  • Brevican
  • Carrier Proteins / genetics*
  • Cell Movement / physiology
  • Chondroitin Sulfate Proteoglycans / genetics*
  • Gene Expression Regulation, Neoplastic
  • Glioma / metabolism*
  • Humans
  • Lectins
  • Lectins, C-Type
  • Nerve Tissue Proteins / genetics*
  • Neuroglia / cytology*


  • BCAN protein, human
  • Brevican
  • Carrier Proteins
  • Chondroitin Sulfate Proteoglycans
  • Lectins
  • Lectins, C-Type
  • Nerve Tissue Proteins