RNA trafficking in myelinating cells

Curr Opin Neurobiol. 1998 Oct;8(5):607-12. doi: 10.1016/s0959-4388(98)80088-3.

Abstract

In the past year, several key molecular components of the RNA trafficking pathway in myelinating cells have been identified: distinct cis-acting elements for RNA transport and localization have been characterized in myelin basic protein mRNA; hnRNP A2 has been identified as a trans-acting factor in oligodendrocytes that binds specifically to the RNA transport sequence; and microtubules and kinesin have been identified as cytoskeletal elements required for RNA transport in oligodendrocytes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Transport / physiology
  • Myelin Sheath / metabolism*
  • Oligodendroglia / metabolism*
  • RNA, Messenger / metabolism*

Substances

  • RNA, Messenger