Linking extracellular survival signals and the apoptotic machinery

Curr Opin Neurobiol. 1998 Oct;8(5):613-8. doi: 10.1016/s0959-4388(98)80089-5.


The survival of cells in multicellular organisms requires continuous stimulation from the extracellular environment. The phosphatidylinositol-3' kinase/Akt signaling cascade has been identified as a critical pathway for the transduction of extracellular survival signals. The finding that the pro-apoptotic protein BAD is a substrate of Akt/PKB has provided the first link between extracellular survival signals and the apoptotic machinery.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Cell Survival / physiology
  • Eukaryotic Cells / cytology*
  • Eukaryotic Cells / metabolism
  • Extracellular Space / metabolism*
  • Signal Transduction / physiology*