Transcranial magnetic stimulation in mania: a controlled study

Am J Psychiatry. 1998 Nov;155(11):1608-10. doi: 10.1176/ajp.155.11.1608.


Objective: Left prefrontal transcranial magnetic stimulation has been reported to have ECT-like effects in depression; therefore, the authors planned a study of transcranial magnetic stimulation in mania.

Method: Sixteen patients completed a 14-day double-blind, controlled trial of right versus left prefrontal transcranial magnetic stimulation at 20 Hz (2-second duration per train, 20 trains/day for 10 treatment days). Mania was evaluated with the Mania Scale, the Brief Psychiatric Rating Scale, and the Clinical Global Impression.

Results: Significantly more improvement was observed in patients treated with right than with left prefrontal transcranial magnetic stimulation.

Conclusions: The therapeutic effect of transcranial magnetic stimulation in mania may show laterality opposite to its effect in depression.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Bipolar Disorder / diagnosis
  • Bipolar Disorder / psychology
  • Bipolar Disorder / therapy*
  • Brief Psychiatric Rating Scale / statistics & numerical data
  • Depressive Disorder / therapy
  • Double-Blind Method
  • Female
  • Functional Laterality / physiology*
  • Humans
  • Male
  • Middle Aged
  • Prefrontal Cortex / physiology*
  • Psychiatric Status Rating Scales / statistics & numerical data
  • Transcranial Magnetic Stimulation / therapeutic use*
  • Treatment Outcome