Escapable and inescapable stress differentially alter extracellular levels of 5-HT in the basolateral amygdala of the rat

Brain Res. 1998 Nov 23;812(1-2):113-20. doi: 10.1016/s0006-8993(98)00960-3.


The effects of escapable and yoked inescapable electric tailshocks on extracellular levels of serotonin (5-HT) in the basolateral amygdala were measured by in vivo microdialysis. Inescapable, but not escapable, shock increased extracellular 5-HT in the amygdala relative to restrained controls. Basal levels of 5-HT were elevated 24 h after inescapable shock, and previously inescapably shocked subjects exhibited an exaggerated 5-HT response to two brief footshocks. Levels of extracellular 5-HIAA did not follow any particular pattern and were not correlated with the changes in 5-HT.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amygdala / metabolism*
  • Analysis of Variance
  • Animals
  • Conditioning, Operant / physiology*
  • Electroshock
  • Escape Reaction / physiology*
  • Hydroxyindoleacetic Acid / metabolism
  • Male
  • Microdialysis
  • Rats
  • Rats, Sprague-Dawley
  • Serotonin / metabolism*
  • Stress, Physiological / metabolism*


  • Serotonin
  • Hydroxyindoleacetic Acid