Rapid response of emotional incontinence to selective serotonin reuptake inhibitors

J Neuropsychiatry Clin Neurosci. Fall 1998;10(4):453-5. doi: 10.1176/jnp.10.4.453.

Abstract

Emotional incontinence (EI) is a perturbing condition characterized by uncontrollable outbursts of exaggerated, involuntary facial expressions and pathological crying or laughter. There is increasing evidence that serotonergic neurotransmission may be damaged in EI. The authors report 4 pathological crying cases (3 poststroke and 1 with multiple sclerosis) and 1 case of pathological laughter after traumatic brain injury. EI improved dramatically with three different selective serotonin reuptake inhibitors (fluoxetine, sertraline, and paroxetine) in the context of these different CNS diseases.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Affective Symptoms / drug therapy*
  • Affective Symptoms / psychology
  • Aged
  • Brain Injuries / complications
  • Brain Injuries / psychology
  • Cerebrovascular Disorders / complications
  • Cerebrovascular Disorders / psychology
  • Crying
  • Fluoxetine / therapeutic use
  • Humans
  • Laughter
  • Male
  • Middle Aged
  • Multiple Sclerosis / complications
  • Multiple Sclerosis / psychology
  • Paroxetine / therapeutic use
  • Serotonin Uptake Inhibitors / therapeutic use*
  • Sertraline / therapeutic use

Substances

  • Serotonin Uptake Inhibitors
  • Fluoxetine
  • Paroxetine
  • Sertraline