Cytomechanics of cadherin-mediated cell-cell adhesion

Curr Opin Cell Biol. 1998 Oct;10(5):572-7. doi: 10.1016/s0955-0674(98)80031-8.


Cadherin-mediated adhesion regulates transitions from initial cell-cell recognition to loosely adherent cell clusters and ultimately, to strongly compacted groups of cells in colonies. Recent studies have described distinct roles for intermolecular clustering of cadherins as well as interactions of cadherin with the actin cytoskeleton in establishing cell-cell adhesion. Integrating cytomechanical roles of cadherin-mediated adhesion will lead to a greater understanding of how cadherins regulate tissue morphogenesis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Actins
  • Animals
  • Biomechanical Phenomena
  • Cadherins / physiology*
  • Cadherins / ultrastructure
  • Cell Adhesion / physiology*
  • Dogs
  • Epithelial Cells / ultrastructure
  • Kidney / ultrastructure
  • Morphogenesis
  • Myosins


  • Actins
  • Cadherins
  • Myosins