Integrin associated proteins

Curr Opin Cell Biol. 1998 Oct;10(5):578-85. doi: 10.1016/s0955-0674(98)80032-x.


Integrin cytoplasmic domains may interact directly with serveral different cytoskeletal proteins and intracellular signaling molecules. Also, integrins interact directly with other transmembrane structures, including transmembrane-4 superfamily (TM4SF) proteins. New evidence suggests that TM4SF proteins may act as linkers between extracellular integrin alpha chain domains and intracellular signaling molecules, such as phosphatidylinositol 4-kinase and protein kinase C.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Membrane / chemistry
  • Cell Polarity
  • Cytoskeletal Proteins / metabolism
  • Integrins / physiology*
  • Membrane Proteins / metabolism
  • Models, Biological
  • Molecular Chaperones / metabolism
  • Protein Binding*
  • Signal Transduction


  • Cytoskeletal Proteins
  • Integrins
  • Membrane Proteins
  • Molecular Chaperones