Matrix metalloproteinase degradation of extracellular matrix: biological consequences

Curr Opin Cell Biol. 1998 Oct;10(5):602-8. doi: 10.1016/s0955-0674(98)80035-5.


Targeted mutagenesis has allowed investigators to perform controlled experiments in mammals and determine the contribution of individual proteins to physiologic and pathologic processes. Recent lessons learned from matrix metalloproteinase gene targeted mice and other in vivo observations have given new life to old concepts regarding the role of proteolytic fragments of extracellular matrix proteins in regulating a variety of critical processes in cell biology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cardiovascular Diseases / etiology
  • Extracellular Matrix / metabolism*
  • Metalloendopeptidases / genetics
  • Metalloendopeptidases / metabolism*
  • Mutagenesis, Site-Directed
  • Neoplasms / etiology
  • Pemphigoid, Bullous / etiology
  • Pulmonary Emphysema / etiology


  • Metalloendopeptidases