DCC and netrins

Curr Opin Cell Biol. 1998 Oct;10(5):609-13. doi: 10.1016/s0955-0674(98)80036-7.


Recent advances highlight the versatility and complexity of this highly conserved axon and cell migration guidance system. Characterization of netrin mutant phenotypes in worm, fly and mouse all suggest that netrins play local as well as long-range roles in guidance. Evidence from multiple sources also indicates that the netrin receptor DCC can mediate both attractive and repulsive responses to netrins.

Publication types

  • Review

MeSH terms

  • Caenorhabditis elegans Proteins*
  • Cell Adhesion Molecules
  • Cell Movement / physiology*
  • Growth Cones / physiology*
  • Nerve Growth Factors*
  • Nervous System / growth & development*
  • Receptors, Nerve Growth Factor*


  • Caenorhabditis elegans Proteins
  • Cell Adhesion Molecules
  • Nerve Growth Factors
  • Receptors, Nerve Growth Factor
  • UNC-40 protein, C elegans