ADAMs: focus on the protease domain

Curr Opin Cell Biol. 1998 Oct;10(5):654-9. doi: 10.1016/s0955-0674(98)80042-2.


ADAMs are proteins containing a disintegrin and metalloproteinase domain. Several important insights were provided in the past year regarding ADAM metalloproteinases. ADAM 10 was implicated in the Notch signaling pathway. ADAM 17 was shown to be the long sought after tumor necrosis factor-alpha convertase and the crystal structure of its metalloproteinase domain was determined.

Publication types

  • Review

MeSH terms

  • ADAM Proteins
  • ADAM17 Protein
  • Disintegrins / metabolism*
  • Drosophila Proteins*
  • Membrane Proteins / metabolism*
  • Metalloendopeptidases / metabolism*
  • Peptide Fragments / metabolism
  • Receptors, Notch
  • Signal Transduction


  • Disintegrins
  • Drosophila Proteins
  • Membrane Proteins
  • Peptide Fragments
  • Receptors, Notch
  • ADAM Proteins
  • KUZ protein, Drosophila
  • Metalloendopeptidases
  • SUP-17 protein, C elegans
  • ADAM17 Protein