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Review
, 2 (5), 633-41

Protein Tyrosine Phosphatases: Mechanisms of Catalysis and Regulation

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Review

Protein Tyrosine Phosphatases: Mechanisms of Catalysis and Regulation

J M Denu et al. Curr Opin Chem Biol.

Abstract

Recent structural information suggests that the HC(X)5R active-site motif defines three distinct evolutionary families of phosphatases that employ a common catalytic mechanism. In two instances, regulation of phosphatase activity employs autoinhibitory mechanisms involving either intermolecular or intramolecular interactions, whereby inhibition is mediated by sterically blocking the active-site cleft.

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