CD40 and epithelial cells: across the great divide

Immunol Today. 1998 Nov;19(11):502-6. doi: 10.1016/s0167-5699(98)01340-1.


The widespread expression of CD40 in normal epithelial cells and carcinoma cells suggests that this receptor has important, additional influences beyond that of regulating immune responses. Here, Lawrence Young and colleagues discuss the effect of CD40 ligation on epithelial cells and consider the role of this pathway in the pathogenesis and treatment of carcinomas.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, Viral
  • CD40 Antigens / physiology*
  • Carcinoma / immunology
  • Epithelial Cells / immunology*
  • Herpesvirus 4, Human / immunology
  • Humans
  • Immunohistochemistry
  • Membrane Proteins / immunology
  • Mice
  • Mice, Knockout
  • Molecular Mimicry / immunology
  • Signal Transduction
  • Viral Matrix Proteins / immunology


  • Antigens, Viral
  • CD40 Antigens
  • EBV-associated membrane antigen, Epstein-Barr virus
  • Membrane Proteins
  • Viral Matrix Proteins