The dynamic structure of the germinal center

Immunol Today. 1998 Nov;19(11):511-4. doi: 10.1016/s0167-5699(98)01327-9.


Analysis of germinal centers (GCs) in chronically inflamed human tonsils has led to the dogma that GCs contain two compartments with separate functions: a dark zone where B cells proliferate and hypermutate; and a light zone where selection and differentiation occur. However, here Stephanie Camacho and colleagues discuss immunohistological analysis of splenic GCs arising de novo that reveal a more plastic structure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • Antigens, Differentiation, B-Lymphocyte / analysis
  • Antigens, Differentiation, T-Lymphocyte / analysis
  • Cell Division
  • Chickens
  • Dendritic Cells / immunology
  • Germinal Center / immunology*
  • Immunohistochemistry
  • Mice
  • Mice, Inbred BALB C
  • Oxazolone / immunology
  • Peanut Agglutinin / immunology
  • Receptors, IgE / analysis
  • Serum Albumin / immunology
  • Spleen / immunology
  • Time Factors


  • Antibodies, Monoclonal
  • Antigens, Differentiation, B-Lymphocyte
  • Antigens, Differentiation, T-Lymphocyte
  • Peanut Agglutinin
  • Receptors, IgE
  • Serum Albumin
  • Oxazolone