Abstract
Analysis of germinal centers (GCs) in chronically inflamed human tonsils has led to the dogma that GCs contain two compartments with separate functions: a dark zone where B cells proliferate and hypermutate; and a light zone where selection and differentiation occur. However, here Stephanie Camacho and colleagues discuss immunohistological analysis of splenic GCs arising de novo that reveal a more plastic structure.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antibodies, Monoclonal
-
Antigens, Differentiation, B-Lymphocyte / analysis
-
Antigens, Differentiation, T-Lymphocyte / analysis
-
Cell Division
-
Chickens
-
Dendritic Cells / immunology
-
Germinal Center / immunology*
-
Immunohistochemistry
-
Mice
-
Mice, Inbred BALB C
-
Oxazolone / immunology
-
Peanut Agglutinin / immunology
-
Receptors, IgE / analysis
-
Serum Albumin / immunology
-
Spleen / immunology
-
Time Factors
Substances
-
Antibodies, Monoclonal
-
Antigens, Differentiation, B-Lymphocyte
-
Antigens, Differentiation, T-Lymphocyte
-
Peanut Agglutinin
-
Receptors, IgE
-
Serum Albumin
-
Oxazolone