Chronic rejection and chronic cyclosporin toxicity in renal allografts

Immunol Today. 1998 Nov;19(11):514-9. doi: 10.1016/s0167-5699(98)01324-3.


Recent evidence indicates that growth factors are critically important in both chronic rejection and chronic cyclosporin A toxicity, suggesting that these two entities share a common pathophysiological pathway, leading to progressive allograft failure. Here, Manuel Pascual and colleagues discuss the relevance of growth factors to chronic allograft nephropathy, and the implications for therapy in view of the great choice of immunosuppressive drugs now available.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blotting, Northern
  • Cell Line
  • Chronic Disease
  • Cyclosporine / adverse effects*
  • Dactinomycin / therapeutic use
  • Graft Rejection / etiology*
  • Graft Rejection / prevention & control
  • Graft Rejection / therapy
  • Growth Substances / immunology
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Kidney Transplantation / immunology*
  • Nucleic Acid Synthesis Inhibitors / therapeutic use
  • RNA, Messenger
  • Rats
  • Transforming Growth Factor beta / immunology


  • Growth Substances
  • Immunosuppressive Agents
  • Nucleic Acid Synthesis Inhibitors
  • RNA, Messenger
  • Transforming Growth Factor beta
  • Dactinomycin
  • Cyclosporine