Physiologic MRI of a tumefactive multiple sclerosis lesion

Neurology. 1998 Nov;51(5):1486-8. doi: 10.1212/wnl.51.5.1486.


Structural and physiologic MRI were performed after subacute onset of left hemiparesis in a patient with MS. MRI showed a large ring-enhancing lesion with surrounding edema and mass effect; differential diagnosis included a neoplasm or a large MS plaque. Physiologic MRI showed reduced blood flow and magnetization transfer, as well as increased diffusion, in the large lesion. Because these findings suggested a tumefactive MS plaque rather than a neoplasm, the patient received steroid treatment for acute MS exacerbation. Three months later the patient improved clinically and on MRI.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Brain / blood supply
  • Brain / pathology*
  • Brain Neoplasms / diagnosis*
  • Diagnosis, Differential
  • Edema
  • Female
  • Follow-Up Studies
  • Hemiplegia
  • Humans
  • Magnetic Resonance Imaging / methods
  • Magnetic Resonance Spectroscopy
  • Multiple Sclerosis / diagnosis*
  • Multiple Sclerosis / drug therapy
  • Regional Blood Flow
  • Steroids / therapeutic use


  • Steroids