Abstract
The authors performed a clinical and serologic follow-up study after 4.2 +/- 1.2 years in 44 patients with clinical signs of neuroborreliosis and specific intrathecal antibody production. All patients had been treated with ceftriaxone 2 g/day for 10 days. Although neurologic deficits decreased significantly, more than half the patients had unspecific complaints resembling a chronic fatigue syndrome and showed persisting positive immunoglobulin M serum titers for Borrelia in the Western blot analysis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Bacterial / blood
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Antibody Formation
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Borrelia burgdorferi Group / immunology*
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Ceftriaxone / therapeutic use*
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Cephalosporins / therapeutic use
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Enzyme-Linked Immunosorbent Assay
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Follow-Up Studies
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Humans
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Immunoglobulin G / blood
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Immunoglobulin M / blood
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Lyme Disease / blood
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Lyme Disease / drug therapy
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Lyme Disease / immunology
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Lyme Disease / physiopathology*
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Nervous System Diseases / blood
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Nervous System Diseases / immunology
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Nervous System Diseases / microbiology
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Nervous System Diseases / physiopathology*
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Retrospective Studies
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Time Factors
Substances
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Antibodies, Bacterial
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Cephalosporins
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Immunoglobulin G
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Immunoglobulin M
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Ceftriaxone