Beta-chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia

Ann Neurol. 1998 Nov;44(5):831-5. doi: 10.1002/ana.410440521.

Abstract

Human immunodeficiency virus-associated dementia (HAD) is associated with increased numbers of activated central nervous system (CNS) macrophages. Chemokines, which regulate infiltration of macrophages, were measured in the cerebrospinal fluid (CSF) of human immunodeficiency virus (HIV)-negative and HIV-positive individuals with and without neurological disease. Monocyte chemotactic protein (MCP)-1 and RANTES (but not MCP-3), macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, or interleukin-8 (IL-8) was higher in HAD. MCP-1 correlated with CSF viral load and severity of dementia, and it increased over time in patients who developed dementia.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • AIDS Dementia Complex / cerebrospinal fluid*
  • AIDS Dementia Complex / immunology
  • Chemokine CCL2 / cerebrospinal fluid*
  • Chemokine CCL5 / cerebrospinal fluid*
  • Chemokine CCL7
  • Cross-Sectional Studies
  • Cytokines*
  • HIV Seronegativity / immunology
  • HIV Seropositivity / cerebrospinal fluid*
  • HIV Seropositivity / immunology
  • Humans
  • Interleukin-8 / cerebrospinal fluid
  • Monocyte Chemoattractant Proteins / cerebrospinal fluid

Substances

  • CCL7 protein, human
  • Chemokine CCL2
  • Chemokine CCL5
  • Chemokine CCL7
  • Cytokines
  • Interleukin-8
  • Monocyte Chemoattractant Proteins