Adeno-associated virus expression systems for gene transfer

Curr Opin Biotechnol. 1998 Oct;9(5):470-5. doi: 10.1016/s0958-1669(98)80031-1.

Abstract

In contrast to other gene delivery systems, adeno-associated virus vectors show long term gene expression without immune response or toxicity. New production methods have increased vector titers and eliminated adenovirus contamination, thereby facilitating effective in vivo use. These advancements will expedite additional animal model studies providing validation for use of this vector in human clinical trials.

Publication types

  • Review

MeSH terms

  • Adenoviridae / genetics
  • Animals
  • Biotechnology
  • Brain / virology
  • Cell Line
  • DNA Helicases / genetics
  • DNA-Binding Proteins*
  • Dependovirus / genetics*
  • Gene Expression
  • Gene Transfer Techniques*
  • Genes, Reporter
  • Genetic Therapy
  • Genetic Vectors*
  • Helper Viruses / genetics
  • Humans
  • Muscles / virology
  • Plasmids / genetics
  • Trans-Activators / genetics

Substances

  • DNA-Binding Proteins
  • Trans-Activators
  • replication initiator protein
  • DNA Helicases