PPARgamma3 mRNA: A Distinct PPARgamma mRNA Subtype Transcribed From an Independent Promoter

FEBS Lett. 1998 Oct 30;438(1-2):55-60. doi: 10.1016/s0014-5793(98)01273-3.

Abstract

PPARgamma is a member of the peroxisome proliferator activated receptors (PPAR) subfamily of nuclear receptors. So far two PPARgamma isoforms, PPARgamma1 and PPARgamma2, were known in mammals. We describe the structure of a novel human PPARgamma subtype, PPARgamma3. The PPARgamma3 mRNA is transcribed from a novel promoter localized 5' of exon A2. PPARgamma3 mRNA expression was restricted to adipose tissue and large intestine. Similar to human PPARgamma1 and -2, PPARy3 is activated by thiazolidinediones and prostaglandin J derivatives and binds with high affinity to a PPRE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 5' Untranslated Regions / genetics
  • Adipose Tissue
  • Adult
  • Animals
  • Base Sequence
  • Cell Line
  • Dimerization
  • Exons / genetics
  • Humans
  • Intestine, Large
  • Molecular Sequence Data
  • Promoter Regions, Genetic / genetics*
  • Prostaglandins / pharmacology
  • Protein Isoforms / genetics
  • RNA, Messenger / analysis
  • Receptors, Cytoplasmic and Nuclear / genetics*
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Receptors, Retinoic Acid / metabolism
  • Response Elements / genetics*
  • Retinoid X Receptors
  • Rosiglitazone
  • Thiazoles / pharmacology
  • Thiazolidinediones*
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism
  • Transcriptional Activation
  • Transfection
  • Tumor Cells, Cultured

Substances

  • 5' Untranslated Regions
  • Prostaglandins
  • Protein Isoforms
  • RNA, Messenger
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Retinoic Acid
  • Retinoid X Receptors
  • Thiazoles
  • Thiazolidinediones
  • Transcription Factors
  • Rosiglitazone