Syndecan-3 in limb skeletal development

Microsc Res Tech. 1998 Oct 15;43(2):123-30. doi: 10.1002/(SICI)1097-0029(19981015)43:2<123::AID-JEMT5>3.0.CO;2-G.


Syndecan-3 is a member of a family of heparan sulfate proteoglycans that function as extracellular matrix receptors and as co-receptors for growth factors and signalling molecules. A variety of studies indicate that syndecan-3 is involved in several aspects of limb morphogenesis and skeletal development. Syndecan-3 participates in limb outgrowth and proliferation in response to the apical ectodermal ridge; mediates cell-matrix and/or cell-cell interactions involved in regulating the onset of chondrogenesis; may be involved in regulating the onset of osteogenesis and joint formation and, plays a role in regulating the proliferation of epiphyseal chondrocytes during endochondral ossification.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bone Development / physiology*
  • Extremities / embryology*
  • Extremities / physiology
  • Humans
  • Membrane Glycoproteins / physiology*
  • Proteoglycans / physiology*
  • Receptors, Fibroblast Growth Factor / physiology*
  • Syndecan-3


  • Membrane Glycoproteins
  • Proteoglycans
  • Receptors, Fibroblast Growth Factor
  • SDC3 protein, human
  • Syndecan-3