Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin

Cancer Res. 1998 Nov 15;58(22):5176-81.


We isolated a novel gene, APCL, that showed significant homology to the adenomatous polyposis coli (APC) tumor suppressor gene. This novel gene, located on chromosome 19p13.3, encodes a protein of 2303 amino acids that is expressed specifically in the brain. The predicted protein of APCL contains five copies of a 20-amino-acid motif (FXVEXTPXCFSRXSSLSSLS). Like APC, this domain of APCL was able to bind to beta-catenin and deplete the intracellular beta-catenin pool. A reporter-gene assay revealed that APCL could also regulate interaction of beta-catenin with T cell-specific transcription factor, although less actively than APC. These results suggest that the APCL protein may be involved in the Wnt/Wingless signal pathway, and the identification of a novel relative of APC may provide new insights into the function of APC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Brain / metabolism*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 19 / genetics*
  • Colonic Neoplasms / metabolism
  • Cytoskeletal Proteins / chemistry
  • Cytoskeletal Proteins / genetics*
  • Cytoskeletal Proteins / metabolism*
  • Genes, APC / genetics*
  • Genes, Tumor Suppressor / genetics*
  • Humans
  • Molecular Sequence Data
  • Organ Specificity
  • Trans-Activators*
  • Tumor Cells, Cultured
  • beta Catenin


  • APC2 protein, human
  • CTNNB1 protein, human
  • Cytoskeletal Proteins
  • Trans-Activators
  • beta Catenin

Associated data

  • GENBANK/AB012162