Polycystic Ovary Syndrome has been related with hyperinsulinemia and insulin resistant, is a heterogenous disorder biochemistry and clinical, as a consequence androgens and insulin hypersecretion, the exacerbation for the chronic anovulation and obesity, which is caused frequently of hirsutism and sterility, moreover is related with great variety metabolic pathologies, cardiac sickness and oncologies disease in long time. The most important in this present review is to determine a role of the hyperinsulinaemia and insulin resistance in this syndrome.