Psyllium improves fecal consistency and prevents enhanced secretory responses in jejunal tissues of piglets infected with ETEC

Dig Dis Sci. 1998 Nov;43(11):2536-41. doi: 10.1023/a:1026611005440.


Infection with enterotoxigenic E. coli (ETEC) induces secretory diarrhea by stimulating net secretion of fluid and electrolytes. We tested the hypothesis that ETEC potentiates jejunal ion secretion induced by other agonists and also examined whether the soluble fiber psyllium ameliorates effects of ETEC-induced pathophysiology. Noninfected or ETEC-infected piglets were given oral electrolyte solution twice daily or electrolyte solution supplemented with psyllium for 48 hr. Jejunal tissues were mounted in flux chambers and basal and stimulated ion transport responses, as reflected by short-circuit current (I(SC)) were measured. The severity of ETEC-induced diarrhea was reduced by psyllium. I(SC) responses to carbachol and 5-hydroxytryptamine were greater in tissues from infected piglets compared with noninfected controls or infected piglets given psyllium. These results suggest that psyllium ameliorates ETEC-induced diarrhea and prevents the enhanced secretory responses to calcium-mediated agonists that occur in ETEC-infected piglet jejunum.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Animals, Suckling
  • Cathartics / pharmacokinetics
  • Cathartics / therapeutic use*
  • Diarrhea / drug therapy
  • Diarrhea / physiopathology
  • Drug Evaluation, Preclinical
  • Enterotoxins / toxicity*
  • Escherichia coli Infections / drug therapy*
  • Escherichia coli Infections / physiopathology
  • Escherichia coli*
  • Feces*
  • Ion Transport / drug effects
  • Jejunum / drug effects*
  • Jejunum / metabolism
  • Nutritional Status
  • Psyllium / pharmacokinetics
  • Psyllium / therapeutic use*
  • Swine


  • Cathartics
  • Enterotoxins
  • Psyllium