Abnormalities in cell cycle control in cancer and their clinical implications

Tumori. Jul-Aug 1998;84(4):421-33.


Recent studies indicate that the functions of several genes that control the cell cycle are altered during the carcinogenic process and that these changes perturb both cell proliferation and genomic stability, thus promoting cell transformation and enhancing the process of tumor progression. The purpose of this paper is to review current information on the role of cyclins and related genes in the control of the mammalian cell cycle, the types of abnormalities in these genes found in human tumors and the possible clinical implications of these findings.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cell Division / physiology
  • Cyclins / genetics
  • Cyclins / physiology
  • Humans
  • Neoplasms / genetics
  • Neoplasms / pathology*


  • Cyclins