Genetics of RAS signaling in C. elegans

Trends Genet. 1998 Nov;14(11):466-72. doi: 10.1016/s0168-9525(98)01592-3.


Genetic analysis of the RAS function in Caenorhabditis elegans has not only clarified the functional relationship of signal transduction proteins, but also led to the discovery of new proteins involved positively or negatively in RAS signaling. The stereotyped development of C. elegans has allowed many of the functions of RAS to be elucidated at the level of fates of individual cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / physiology*
  • Caenorhabditis elegans Proteins*
  • Gene Expression Regulation, Developmental*
  • Genes, ras*
  • Germ Cells / physiology
  • Helminth Proteins / genetics
  • Helminth Proteins / metabolism*
  • Homeodomain Proteins / genetics
  • Homeodomain Proteins / metabolism
  • Larva
  • Signal Transduction
  • ras Proteins / genetics*
  • ras Proteins / metabolism


  • Caenorhabditis elegans Proteins
  • Helminth Proteins
  • Homeodomain Proteins
  • let-60 protein, C elegans
  • ras Proteins