Management of nasal aspergillosis in a dog with a single, noninvasive intranasal infusion of clotrimazole

J Am Anim Hosp Assoc. Nov-Dec 1998;34(6):487-92. doi: 10.5326/15473317-34-6-487.


An 11-year-old, spayed female keeshond was presented for unilateral epistaxis and serous nasal discharge of four weeks duration. Initial nasal radiographs, rhinoscopy, and histopathology suggested severe, destructive lymphoplasmacytic rhinitis. The patient deteriorated while receiving an anti-inflammatory dose of prednisone. A computed tomographic scan of the nose demonstrated a soft-tissue density in both the right nasal cavity and frontal sinus. Samples for histopathology obtained at surgery were diagnostic for nasal aspergillosis. All clinical signs resolved with a single, noninvasive infusion of intranasal clotrimazole and a four-week course of oral itraconazole.

Publication types

  • Case Reports

MeSH terms

  • Administration, Intranasal
  • Animals
  • Antifungal Agents / therapeutic use*
  • Aspergillosis / drug therapy
  • Aspergillosis / veterinary*
  • Clotrimazole / therapeutic use*
  • Dogs
  • Female
  • Nasal Cavity / microbiology
  • Nasal Cavity / pathology
  • Nose Diseases / drug therapy
  • Nose Diseases / veterinary*


  • Antifungal Agents
  • Clotrimazole