Abstract
SOX proteins contain a conserved HMG-related DNA-binding domain. They fulfill essential functions during the development of animals. Mutations in several SOX genes have been implicated in human diseases. We present here a new set of PCR primers designed to amplify a broad range of SOX HMG-box sequences. These primers facilitated the cloning of several new SOX HMG boxes from human genomic DNA, revealing unexpected complexity of the SOX gene family.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Cloning, Molecular
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Conserved Sequence
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DNA Primers
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / genetics*
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High Mobility Group Proteins / biosynthesis
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High Mobility Group Proteins / chemistry
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High Mobility Group Proteins / genetics*
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Humans
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Mammals
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Mice
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Molecular Sequence Data
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Multigene Family*
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Nuclear Proteins*
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Phylogeny
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Polymerase Chain Reaction
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Recombinant Proteins / biosynthesis
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Recombinant Proteins / chemistry
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Sequence Alignment
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Sequence Homology, Amino Acid
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Sex-Determining Region Y Protein
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Transcription Factors*
Substances
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DNA Primers
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DNA-Binding Proteins
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High Mobility Group Proteins
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Nuclear Proteins
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Recombinant Proteins
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Sex-Determining Region Y Protein
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Transcription Factors
Associated data
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GENBANK/AF032449
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GENBANK/AF032450
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GENBANK/AF032451
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GENBANK/AF032452
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GENBANK/AF032453
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GENBANK/AF032454