Postnatal exposure to chlorinated dioxins and related chemicals on thyroid hormone status in Japanese breast-fed infants

Chemosphere. Oct-Nov 1998;37(9-12):1789-93. doi: 10.1016/s0045-6535(98)00244-6.


Effects of postnatal exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and coplanar polychlorinated biphenyls (Co-PCBs) on thyroid hormone status were studied in the peripheral blood of 36 breast-fed Japanese infants. Estimated total intakes of these chemicals in toxic equivalent quantity (TEQ) converted into 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) from the breast milk significantly and negatively correlated with the levels of triiodothyronine (T3) and thyroxine (T4) in the blood of breast-fed babies. Therefore, exposure to background levels of the highly toxic organochlorine chemicals through the breast milk may cause some effects on thyroid hormone status in Japanese infants.

MeSH terms

  • Adult
  • Benzofurans / adverse effects*
  • Breast Feeding*
  • Environmental Exposure
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Milk, Human / chemistry*
  • Polychlorinated Biphenyls / adverse effects*
  • Polychlorinated Dibenzodioxins / adverse effects
  • Polychlorinated Dibenzodioxins / analogs & derivatives*
  • Thyroid Function Tests
  • Thyroid Hormones / analysis*
  • Thyroid Hormones / metabolism


  • Benzofurans
  • Polychlorinated Dibenzodioxins
  • Thyroid Hormones
  • Polychlorinated Biphenyls