Analysis of the signals generated by networks of neurons coupled to planar arrays of microtransducers in simulated experiments

Biosens Bioelectron. 1998 Sep 15;13(6):601-12. doi: 10.1016/s0956-5663(98)00015-3.


Planar microelectrode arrays can be used to characterize the dynamics of networks of neurons reconstituted in vitro. In this paper simulations related to experiments of the electrical activity recording by means of planar arrays of microtransducers coupled to networks of neurons are described. First a detailed model of single and synaptically connected neurons is given, appropriate to computer simulate the action potentials of neuronal populations. Then 'realistic' signals are generated. These signals are intended to reproduce, both in shape and intensity, those recorded by a microelectrode array. Typical experimental conditions are considered, and a detailed analysis given, of the bioelectronic coupling and of its influence on the shape of the recorded signals. Finally, simulated experiments dealing with dorsal root ganglia neurons are described and analysed in comparison with experimental results reported in the literature and obtained in our own laboratory. The effectiveness of the planar microelectrode technique is briefly discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cells, Cultured
  • Computer Simulation
  • Electric Stimulation
  • Ganglia, Spinal / physiology
  • Humans
  • Microelectrodes
  • Nerve Net*
  • Stimulation, Chemical
  • Synaptic Transmission*