NACP/alpha-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy

Acta Neuropathol. 1998 Nov;96(5):439-44. doi: 10.1007/s004010050917.


We examined neuronal cytoplasmic inclusions (NCIs) and oligodendrocytic glial cytoplasmic inclusions (GCIs) in the pontine nuclei in multiple system atrophy (MSA) using antibodies against the non-amyloid beta component of Alzheimer's disease amyloid precursor protein (NACP/alpha-synuclein). Our immunohistochemical study revealed that anti-NACP antibodies labeled both NCIs and GCIs. Immunoelectron microscopy showed that positive reaction products were localized on the 15- to 30-nm-thick filamentous components of NCIs and GCIs. The present study demonstrates that NACP is associated with cytoplasmic inclusions of MSA, and suggests a role of NACP in abnormal filament aggregation in neuronal degeneration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Female
  • Humans
  • Immunohistochemistry
  • Inclusion Bodies / metabolism*
  • Inclusion Bodies / pathology
  • Male
  • Microscopy, Immunoelectron
  • Middle Aged
  • Multiple System Atrophy / metabolism*
  • Multiple System Atrophy / pathology
  • Nerve Tissue Proteins / metabolism*
  • Neurofibrils / metabolism
  • Neurofibrils / pathology
  • Neurons / metabolism*
  • Neurons / pathology
  • Oligodendroglia / metabolism*
  • Oligodendroglia / pathology
  • Pons / metabolism*
  • Pons / pathology
  • Rats
  • Synucleins


  • Nerve Tissue Proteins
  • Synucleins