Spectrofluorimetric determination of tacrine in pharmaceuticals and spiked human serum

Analyst. 1998 Jul;123(7):1575-6. doi: 10.1039/a801864b.


A spectrofluorimetric method to determine tacrine is proposed and applied to the determination of tacrine in human serum and pharmaceuticals. The fluorimetric method allows the determination of 1-70 ng ml-1 of tacrine in aqueous solutions containing acetic acid-sodium acetate buffer (pH 5.6) with lambda exc = 242 nm and lambda em = 362 nm.

MeSH terms

  • Cholinesterase Inhibitors / analysis*
  • Cholinesterase Inhibitors / blood
  • Humans
  • Spectrometry, Fluorescence
  • Tacrine / analysis*
  • Tacrine / blood


  • Cholinesterase Inhibitors
  • Tacrine