Ephrin-A1 is expressed at sites of vascular development in the mouse

Mech Dev. 1998 Oct;77(2):201-4. doi: 10.1016/s0925-4773(98)00142-7.


B61 (ephrin-A1), a ligand for eph receptor-protein tyrosine kinases, possesses angiogenic and endothelial cell chemoattractant activity. We report the expression profile of ephrin-A1 during mouse embryogenesis (7.25 to 10.5 days post-coitum (dpc)). Ephrin-A1 expression was first detected in the caudal end of the primitive streak and the developing allantois. At mid head fold stage, ephrin-A1 transcripts were observed in the anterior pharyngeal endoderm that underlies the site of the future heart. In 8.0 to 8.5 dpc embryos, ephrin-A1 was expressed in presumptive endocardial cells, the dorsal aorta, and the primary head veins. In 9.5 to 10.5 dpc embryos, ephrin-A1 RNA was detected in intersomitic vessels and the limb bud vasculature. Each site of ephrin-A1 expression corresponded to regions of vasculogenesis and/or angiogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blood Vessels / embryology
  • Embryonic Induction / genetics
  • Endothelium, Vascular / embryology*
  • Ephrin-A1
  • Gene Expression Regulation, Developmental*
  • Head / blood supply
  • Head / embryology
  • Limb Buds / metabolism
  • Mesoderm
  • Mice
  • Proteins / genetics*
  • Proteins / metabolism
  • Somites / metabolism


  • Ephrin-A1
  • Proteins