Dopamine-dependent behavioural stimulation by non-peptide delta opioids BW 373U86 and SNC 80: 3. Facilitation of D1 and D2 responses in unilaterally 6-hydroxydopamine-lesioned rats

Behav Pharmacol. 1998 Feb;9(1):15-21.

Abstract

In unilaterally 6-hydroxydopamine lesioned rats the ability of two non-peptide delta-opioid agonists, BW 373U86 and SNC 80, to induce motor asymmetries, alone or in combination with low doses of specific D1 or D2 agonists, was investigated. BW 373U86 and SNC 80 failed to induce motor asymmetries by themselves, but elicited contralateral turning after pretreatment with a dose of SKF 38393, a D1 agonist, or quinpirole, a D2 agonist, which per se did not induce contralateral turning. BW 373U86 also potentiated contralateral turning induced by threshold doses of quinpirole. Facilitation of D1-dependent contralateral turning was associated with a potentiation of c-fos expression, as estimated by Fos-like immunoreactivity, in the dorsal caudate-putamen, particularly in its lateral aspect. Potentiation of D2-dependent contralateral turning was associated with a reduction of c-fos expression in the medial caudate-putamen. It is concluded that stimulation of delta-opioid receptors facilitates the expression of D1 and D2 responses arising from the denervated striatum.

MeSH terms

  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology
  • Animals
  • Behavior, Animal / drug effects
  • Behavior, Animal / physiology*
  • Benzamides / pharmacology*
  • Brain Chemistry / drug effects*
  • Conditioning, Operant / drug effects*
  • Dopamine / physiology*
  • Dopamine Agonists / pharmacology
  • Immunohistochemistry
  • Male
  • Microdialysis
  • Oxidopamine
  • Piperazines / pharmacology*
  • Proto-Oncogene Proteins c-fos / biosynthesis
  • Proto-Oncogene Proteins c-fos / genetics
  • Quinpirole / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Dopamine D1 / drug effects*
  • Receptors, Dopamine D2 / drug effects*
  • Sympathectomy, Chemical*

Substances

  • Benzamides
  • Dopamine Agonists
  • Piperazines
  • Proto-Oncogene Proteins c-fos
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • BW 373U86
  • 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide
  • Quinpirole
  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
  • Oxidopamine
  • Dopamine