Syringoma: a review of twenty-nine cases

Acta Derm Venereol. 1998 Nov;78(6):460-2. doi: 10.1080/000155598442791.


The purpose of our study was to identify the clinical characteristics, epidemiologic data and histologic features in 29 cases of syringoma with a duration of lesions prior to the observation between 1 and 25 years. Only one patient complained of moderate itching. In two cases the lesion was solitary, in another the papules formed a lichenified plaque. In six patients only the eyelids were involved and in two patients a symmetrical localization on the forearms was observed. The other 18 patients showed generalized syringoma, 16 with an eruptive onset, 6 of which were familial. One of our cases showed lesions mimicking urticaria pigmentosa and two patients were affected by Down's syndrome. In two cases, histopathology showed association between syringoma and a melanocytic naevus and in one patient with a solitary lesion a clear cell syringoma was observed.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Diagnosis, Differential
  • Down Syndrome / complications
  • Eyelid Neoplasms / pathology
  • Female
  • Follow-Up Studies
  • Forearm / pathology
  • Humans
  • Hyperpigmentation / pathology
  • Lichenoid Eruptions / pathology
  • Male
  • Middle Aged
  • Neoplasms, Multiple Primary / pathology
  • Nevus, Pigmented / pathology
  • Pruritus / pathology
  • Sweat Gland Neoplasms / genetics
  • Sweat Gland Neoplasms / pathology*
  • Syringoma / genetics
  • Syringoma / pathology*
  • Urticaria Pigmentosa / diagnosis