Pathways of beta-hydroxybutyrate contribution to metabolism of acetyl-CoA and acetylcholine in rat brain nerve terminals

Folia Neuropathol. 1997;35(4):244-6.

Abstract

beta-hydroxybutyrate increased concentration of acetyl-CoA in mitochondria of resting and in cytoplasm of Ca-activated rat brain synaptosomes. Adequate rise of Ca-evoked acetylcholine release was also observed. The activation was abolished by verapamil. It indicates that beta-hydroxybutyrate-derived acetyl-CoA is transported from mitochondria to synaptoplasm by direct Ca-dependent transport mechanism. Presented data evidence that level of synaptoplasmic acetyl-CoA plays an important role in the regulation of cholinergic activity in the brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3-Hydroxybutyric Acid / pharmacology*
  • Acetyl Coenzyme A / metabolism*
  • Acetylcholine / metabolism*
  • Animals
  • Brain / drug effects
  • Brain / metabolism*
  • Calcium / pharmacology
  • Cholinergic Fibers / drug effects
  • Cholinergic Fibers / metabolism
  • Cytoplasm / drug effects
  • Cytoplasm / metabolism
  • Male
  • Mitochondria / drug effects
  • Mitochondria / metabolism
  • Pyruvic Acid / metabolism
  • Pyruvic Acid / pharmacology
  • Rats
  • Rats, Wistar
  • Synaptosomes / drug effects*
  • Synaptosomes / metabolism

Substances

  • Acetyl Coenzyme A
  • Pyruvic Acid
  • Acetylcholine
  • Calcium
  • 3-Hydroxybutyric Acid