Inhibition of cAMP-phosphodiesterase by biflavones of Ginkgo biloba in rat adipose tissue

J Nat Prod. 1998 Nov;61(11):1386-7. doi: 10.1021/np970569m.

Abstract

This work compares the inhibition of cAMP-phosphodiesterase in rat adipose tissue by a mixture of Ginkgo biloba biflavones with the effect of individual dimeric flavonoids. The degree of enzyme inhibition by G. biloba biflavones was amentoflavone > bilobetin > sequoiaflavone > ginkgetin = isoginkgetin. Sciadopitysin was almost inactive.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
  • Adipose Tissue / drug effects
  • Adipose Tissue / enzymology*
  • Animals
  • Dose-Response Relationship, Drug
  • Flavonoids / isolation & purification*
  • Flavonoids / pharmacology
  • Ginkgo biloba / chemistry*
  • In Vitro Techniques
  • Male
  • Phosphodiesterase Inhibitors / isolation & purification*
  • Phosphodiesterase Inhibitors / pharmacology
  • Plants, Medicinal*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Flavonoids
  • Phosphodiesterase Inhibitors
  • 3',5'-Cyclic-AMP Phosphodiesterases