Drug-induced acute interstitial nephritis

Ren Fail. 1998 Nov;20(6):809-19. doi: 10.3109/08860229809045178.


Acute interstitial nephritis (AIN) is a form of inflammatory renal disease affecting predominantly the tubules and the interstitium. Drugs, particularly beta-lactam antibiotics and non-steroidal anti-inflammatory drugs, are currently the most common causes. The pathogenesis of drug-induced AIN is complex but there is good clinical evidence for an immune-mediated reaction. Clinical findings may be variable depending on the drug involved and the individual response. Most patients recover from the acute renal failure; however, in older patients or in patients with pre-existing renal insufficiency the recovery of renal function may be incomplete.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Anti-Bacterial Agents / adverse effects
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Diuretics / adverse effects
  • Humans
  • Nephritis, Interstitial / chemically induced*
  • Nephritis, Interstitial / physiopathology


  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Diuretics