ST segment elevation induced by class IC antiarrhythmic agents: underlying electrophysiologic mechanisms and insights into drug-induced proarrhythmia

J Cardiovasc Electrophysiol. 1998 Nov;9(11):1167-72. doi: 10.1111/j.1540-8167.1998.tb00088.x.


Three patients in whom Class IC sodium channel blockers induced ST segment elevation in leads V1 through V3 are described. The underlying electrophysiologic mechanism, implications for drug-induced proarrhythmia, and the relationship of the finding to the Brugada syndrome type of idiopathic ventricular fibrillation are discussed.

Publication types

  • Case Reports

MeSH terms

  • Anti-Arrhythmia Agents / pharmacology*
  • Arrhythmias, Cardiac / chemically induced*
  • Arrhythmias, Cardiac / physiopathology
  • Atrial Fibrillation / physiopathology
  • Cardiomyopathy, Dilated / physiopathology
  • Electrocardiography / drug effects*
  • Electrophysiology
  • Encainide / pharmacology
  • Flecainide / pharmacology
  • Humans
  • Male
  • Middle Aged
  • Sodium Channel Blockers
  • Ventricular Fibrillation / physiopathology


  • Anti-Arrhythmia Agents
  • Sodium Channel Blockers
  • Flecainide
  • Encainide