Protein and lipid sorting from the trans-Golgi network to the plasma membrane in polarized cells

Semin Cell Dev Biol. 1998 Oct;9(5):503-9. doi: 10.1006/scdb.1998.0258.


The targeting of proteins and lipids to the cell surface domains of polarized cells is not a simple bulk flow process but requires sorting into distinct apical and basolateral pathways from the trans-Golgi network. Here, we describe the sorting determinants in the cargo molecules, the cellular sorting machineries responsible for the hierarchical read-out of the signals, and the mechanisms of cargo delivery. Furthermore, we discuss the implications of these findings for protein-lipid interactions in other cellular machineries.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Transport / physiology*
  • Cell Membrane / metabolism*
  • Cell Polarity*
  • Cholesterol / physiology
  • Eukaryotic Cells / physiology*
  • Eukaryotic Cells / ultrastructure
  • Glycosphingolipids / physiology
  • Humans
  • Intracellular Membranes / physiology
  • Lipid Bilayers
  • Membrane Fusion
  • Membrane Lipids / metabolism*
  • Membrane Proteins / metabolism*
  • Models, Biological
  • Polysaccharides / physiology
  • Protein Sorting Signals / physiology


  • Glycosphingolipids
  • Lipid Bilayers
  • Membrane Lipids
  • Membrane Proteins
  • Polysaccharides
  • Protein Sorting Signals
  • Cholesterol