Molecular mechanisms of meiotic maturation and arrest in fish and amphibian oocytes

Semin Cell Dev Biol. 1998 Oct;9(5):569-79. doi: 10.1006/scdb.1998.0251.

Abstract

Fish and amphibian oocytes provide excellent experimental systems for both biochemical and cytological analyses of regulatory mechanisms of meiotic maturation and arrest. Recent work shows that despite the adoption of common players, such as maturation-promoting factor (MPF), c-mos proto-oncogene product (Mos), and mitogen-activated protein kinase (MAPK), there is clear species-specificity in the mechanisms, probably due to the difference in the states of inactive MPF in immature oocytes. However, it has also been revealed that the mechanisms controlling meiotic maturation and arrest include ubiquitous pathways; The translational activation of masked mRNAs encoding Mos and cyclin B for initiating maturation and the Mos-MAPK pathway for maintaining metaphase arrest.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amphibians / physiology*
  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases / physiology
  • Cyclin B / genetics
  • Cyclin B / physiology
  • Egg Proteins / metabolism
  • Female
  • Fishes / physiology*
  • Gene Expression Regulation, Developmental
  • Genes, mos
  • Maturation-Promoting Factor / metabolism
  • Maturation-Promoting Factor / physiology
  • Meiosis / physiology*
  • Metaphase
  • Oocytes / cytology*
  • Oogenesis / physiology*
  • Phosphorylation
  • Prophase
  • Protein Biosynthesis
  • Protein Precursors / metabolism
  • Protein Processing, Post-Translational
  • Proto-Oncogene Proteins c-mos / physiology
  • RNA, Messenger / metabolism
  • Species Specificity
  • Xenopus laevis / physiology

Substances

  • Cyclin B
  • Egg Proteins
  • Protein Precursors
  • RNA, Messenger
  • maturation-promoting factor precursor
  • Proto-Oncogene Proteins c-mos
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Maturation-Promoting Factor