Hypoglycemic effect of water-soluble polysaccharide from Auricularia auricula-judae Quel. on genetically diabetic KK-Ay mice

Biosci Biotechnol Biochem. 1998 Oct;62(10):1898-903. doi: 10.1271/bbb.62.1898.


The hypoglycemic effect of water-soluble polysaccharide(FA) from fruiting bodies of Auricularia auricula-judae Quel. was investigated on genetically diabetic mice (KK-Ay) from 10 to 14 weeks of age. Male mice were divided into 3 groups, the control group and FA-fed group having free access to the control diet or FA diet (30 g of FA/kg of diet). The food-restricted group had restricted access to the control diet at the level of the diet consumed by the FA-fed group. Compared with the control group, FA supplementation had a significant effect in lowering plasma glucose, insulin, urinary glucose, and food intake. FA administration also increased the tolerance to intraperitoneal glucose loading and the hepatic glycogen content. In the food-restricted group, the reduced food intake slightly lowered the plasma and urinary glucose levels, but did not improve hyperinsulinemia and glucose tolerance. This study shows that FA had a hypoglycemic effect on KK-Ay mice, and the reduced food consumption was not a major factor which contributed to the hypoglycemic action of FA.

MeSH terms

  • Agaricales / chemistry*
  • Animals
  • Blood Glucose / metabolism
  • Diabetes Mellitus, Type 2 / metabolism*
  • Dietary Fiber / pharmacology*
  • Eating / drug effects
  • Hypoglycemia / chemically induced*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Polysaccharides / pharmacology*


  • Blood Glucose
  • Dietary Fiber
  • Polysaccharides