Reduced nociceptive behavior in islet amyloid polypeptide (amylin) knockout mice

Brain Res Mol Brain Res. 1998 Dec 10;63(1):180-3. doi: 10.1016/s0169-328x(98)00269-1.


Islet amyloid polypeptide (IAPP or amylin) is predominantly expressed by insulin cells, but occurs also in primary sensory neurons in the rat. Here, using mice targeted for a null mutation in the IAPP gene, we establish murine expression of IAPP in sensory neurons; its distribution in a population of calcitonin gene-related peptide-containing neurons in the spinal cord and dorsal root ganglion is similar to that previously described in the rat. We also report the IAPP mutant mice display a reduced pain response in the paw formalin test. Adjuvant-induced joint inflammation was not altered in IAPP mutants, arguing against a peripheral inflammatory abnormality. These findings lead us to suggest that IAPP has a pro-nociceptive function in primary sensory neurons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid / genetics*
  • Animals
  • Ankle Joint / pathology
  • Behavior, Animal / physiology*
  • Calcitonin Gene-Related Peptide / analysis
  • Disinfectants
  • Formaldehyde
  • Freund's Adjuvant
  • Ganglia, Spinal / chemistry
  • Ganglia, Spinal / cytology
  • Islet Amyloid Polypeptide
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout / physiology*
  • Neuritis / chemically induced
  • Neuritis / physiopathology
  • Neurons, Afferent / chemistry
  • Neurons, Afferent / physiology
  • Nociceptors / physiology*
  • Somatosensory Cortex / cytology
  • Somatosensory Cortex / physiology
  • Spinal Cord / chemistry
  • Spinal Cord / cytology
  • Substance P / analysis


  • Amyloid
  • Disinfectants
  • Islet Amyloid Polypeptide
  • Formaldehyde
  • Substance P
  • Freund's Adjuvant
  • Calcitonin Gene-Related Peptide